Born with a rare genetic disorder called progeria, Sam Berns knew he'd be facing more obstacles in life than most. This didn't stop him from taking charge of his own happiness. In this moving and inspirational talk, Berns lays out the three principles of the personal philosophy that allowed him to do so.

Today we know the molecular cause of 4,000 diseases, but treatments are available for only 250 of them. So what's taking so long? Geneticist and physician Francis Collins explains why systematic drug discovery is imperative, even for rare and complex diseases, and offers a few solutions -- like teaching old drugs new tricks.